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Sansho Intake Modulates Ileum Activity in Stress-loaded Rats

Received: 25 June 2015     Accepted: 27 June 2015     Published: 3 July 2015
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Abstract

Sansho (Japanese pepper) is a common spice widely used in Japanese cuisine. In addition, it is also an important component in Kampo medicine, such as in Daiken Chuto, which stimulates gastrointestinal motility and improves postoperative ileus. On the other hand, we previously reported that gravity stress loading produce negative effects on ileal movements. In the present study, we report changes in ileal motility after gravity-stress with and without Sansho intake in male and female rats. Ileal movements were activated by topical Acetylcholine (Ach) application, and maximum amplitudes (MA) of the evoked contraction were compared. Clear tonic patterns were observed in the ileal motility after Ach application. After short-term stress, there were no significant differences in MA between control and Sansho-intake groups in both sexes. However, after long-term stress-loading, significant enhancement of MA was observed in Sansho-intake group in males, but not in females. The present study showed that SAN affected Ach-induced ileal motility in the male, but not in the female after long-term stress loading, indicating sex differences in effects of Sansho intake. It is suggested that Sansho is more effective in males than in females to decrease negative stress response.

Published in Journal of Food and Nutrition Sciences (Volume 3, Issue 3-1)

This article belongs to the Special Issue Effects of Foods on Gastrointestinal, Metabolic and Immunological Function

DOI 10.11648/j.jfns.s.2015030301.13
Page(s) 9-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Sansho (Japanese Pepper), Ileum, Stress, Motility, Sex Difference, Rat

References
[1] Jiang, L., Kubota, K. (2004) Differences in the volatile components and their odor characteristics of green and ripe fruits and dried pericarp of Japanese pepper (Xanthoxylum piperitum DC.). J Agric Food Chem. 52:197-203.
[2] Yamada, Y. (2009) Suppressive Compounds from Japanese Pepper (Zanthoxylum piperitum) against the Fishy Trimethylamine Odor. J. Home Econ. Jpn. 60:723-726.
[3] Ono, H., Nishio, S., Tsurii, J., Kawamoto, T., Sonomoto, K., Nakayama ,J. (2014) Effects of Japanese pepper and red pepper on the microbial community during nukadoko fermentation. Biosci Microbiota Food Health. 34:1-9.
[4] Okada, K., Kawai, M., Hirono, S., Miyazawa, M., Shimizu, A., Kitahata, Y., Yamaue, H. (2015) Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy. Hepatogastroenterology.62:466-71.
[5] Akamaru. Y., Takahashi, T., Nishida, T., Omori, T., Nishikawa, K., Mikata, S., Yamamura, N., Miyazak,i S., Noro, H., Takiguchi, S., Mori, M., Doki, Y. (2015) Effects of daikenchuto, a Japanese herb, on intestinal motility after total gastrectomy: a prospective randomized trial. J Gastrointest Surg. 2015 19:467-72.
[6] Endo, M., Hori, M., Ozaki, H., Oikawa, T., Hanawa, T. (2014) Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors. J Gastroenterol. 49:1026-39.
[7] Kimoto, M, Zeredo J.L., Ota, M.S., Nihei, Z., Toda, K. (2014) Comparison of stress-induced modulation of smooth-muscle activity between ileum and colon in male rats. Auton Neurosci. 183:8-11.
[8] Kimoto, M., Zeredo, J.L., Toda, K. (2012) Hypergravity conditioning on ileal movements in rats. Aviat Space Environ Med. 83:483-487.
[9] Fukushima, A., Hagiwara, H., Fujioka, H., Kimura, F., Akema, T., Funabashi ,T. (2015). Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus. Front Neurosci. ;9: eCollection doi: 10.3389/fnins.2015.00088.
[10] Papier, K., Ahmed, F., Lee, P., Wiseman, J. (2015) Stress and dietary behaviour among first-year university students in Australia: sex differences. Nutrition. 31:324-330.
[11] Spaeth, A.M., Dinges, D.F., Goel, N.(2014) Sex and race differences in caloric intake during sleep restriction in healthy adults. Am J Clin Nutr. 100:559-566.
[12] McEwen, B. S. (2011). Stress, sex and neural adaptation to achanging environment: mechanisms of neuronal remodeling. Ann. N. Y. Acad. Sci. 1204 (Suppl): 38–59.
[13] Maniam, J., Morris, M. J. (2012). The link between stress and feeding behaviour. Neuropharmacol. 63:97-110.
[14] Yau, Y. H., Potenza, M. N. (2013). Stress and eating behaviors. Minerva Endocrinology 38:255-267.
[15] Lucassen, P. J., Pruessner, J., Sousa, N., Almeida, O. F., Van Dam, A. M., Rajkowska, G., Swaab, D. F., Czéh, B. (2014). Neuropathology of stress. Acta Neuropathol. 127:109-135.
[16] Keatonga, L., Hayesa, J., Moanea, S., Lehaneb, M., O’Dohertyc, S., Kingstond, R., Fureyb, A. (2014). The effect of simulated gastro-intestinal conditions on the antioxidant activity of herbal preparations made from native Irish hawthorn. J. Herbal Med. 4:127-133.
[17] Allisona, D. B., Fontaineb, K. R., Heshkaa, S., Mentorec, J. L., Heymsfieldc, S. B. (2001). Alternative treatments for weight loss: A critical review. Critical Reviews in Food Science and Nutrition. 41:1-28.
[18] Manabe, N., Camilleri, M., Rao, A., Wong, B.S., Burton, D., Busciglio, I. (2010) Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans. Am J Physiol Gastrointest Liver Physiol. 298:970-975
[19] Tokita, Y., Akiho, H., Nakamura, K., Ihara, E., Yamamoto, M. (2015) Contraction of gut smooth muscle cells assessed by fluorescence imaging. J Pharmacol Sci. 127:344-351.
[20] Koo, J.Y., Jang, Y., Cho, H., Lee, C.H., Jang, K.H., Chang, Y.H., Shin, J., Oh, U. (2007) Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci. 26:1139-1147.
[21] Kubota, K., Ohtake, N., Ohbuchi, K., Mase, A., Imamura, S., Sudo, Y., Miyano, K.,Yamamoto,M., Kono,T., Uezono, Y. (2015) Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9. Am J Physiol Gastrointest Liver Physiol. 308(7): G579–G590.
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  • APA Style

    Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda. (2015). Sansho Intake Modulates Ileum Activity in Stress-loaded Rats. Journal of Food and Nutrition Sciences, 3(3-1), 9-12. https://doi.org/10.11648/j.jfns.s.2015030301.13

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    ACS Style

    Mari Kimoto; Jorge L. Zeredo; Masato S. Ota; Zenro Nihei; Kazuo Toda. Sansho Intake Modulates Ileum Activity in Stress-loaded Rats. J. Food Nutr. Sci. 2015, 3(3-1), 9-12. doi: 10.11648/j.jfns.s.2015030301.13

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    AMA Style

    Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda. Sansho Intake Modulates Ileum Activity in Stress-loaded Rats. J Food Nutr Sci. 2015;3(3-1):9-12. doi: 10.11648/j.jfns.s.2015030301.13

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  • @article{10.11648/j.jfns.s.2015030301.13,
      author = {Mari Kimoto and Jorge L. Zeredo and Masato S. Ota and Zenro Nihei and Kazuo Toda},
      title = {Sansho Intake Modulates Ileum Activity in Stress-loaded Rats},
      journal = {Journal of Food and Nutrition Sciences},
      volume = {3},
      number = {3-1},
      pages = {9-12},
      doi = {10.11648/j.jfns.s.2015030301.13},
      url = {https://doi.org/10.11648/j.jfns.s.2015030301.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.s.2015030301.13},
      abstract = {Sansho (Japanese pepper) is a common spice widely used in Japanese cuisine. In addition, it is also an important component in Kampo medicine, such as in Daiken Chuto, which stimulates gastrointestinal motility and improves postoperative ileus. On the other hand, we previously reported that gravity stress loading produce negative effects on ileal movements. In the present study, we report changes in ileal motility after gravity-stress with and without Sansho intake in male and female rats. Ileal movements were activated by topical Acetylcholine (Ach) application, and maximum amplitudes (MA) of the evoked contraction were compared. Clear tonic patterns were observed in the ileal motility after Ach application. After short-term stress, there were no significant differences in MA between control and Sansho-intake groups in both sexes. However, after long-term stress-loading, significant enhancement of MA was observed in Sansho-intake group in males, but not in females. The present study showed that SAN affected Ach-induced ileal motility in the male, but not in the female after long-term stress loading, indicating sex differences in effects of Sansho intake. It is suggested that Sansho is more effective in males than in females to decrease negative stress response.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Sansho Intake Modulates Ileum Activity in Stress-loaded Rats
    AU  - Mari Kimoto
    AU  - Jorge L. Zeredo
    AU  - Masato S. Ota
    AU  - Zenro Nihei
    AU  - Kazuo Toda
    Y1  - 2015/07/03
    PY  - 2015
    N1  - https://doi.org/10.11648/j.jfns.s.2015030301.13
    DO  - 10.11648/j.jfns.s.2015030301.13
    T2  - Journal of Food and Nutrition Sciences
    JF  - Journal of Food and Nutrition Sciences
    JO  - Journal of Food and Nutrition Sciences
    SP  - 9
    EP  - 12
    PB  - Science Publishing Group
    SN  - 2330-7293
    UR  - https://doi.org/10.11648/j.jfns.s.2015030301.13
    AB  - Sansho (Japanese pepper) is a common spice widely used in Japanese cuisine. In addition, it is also an important component in Kampo medicine, such as in Daiken Chuto, which stimulates gastrointestinal motility and improves postoperative ileus. On the other hand, we previously reported that gravity stress loading produce negative effects on ileal movements. In the present study, we report changes in ileal motility after gravity-stress with and without Sansho intake in male and female rats. Ileal movements were activated by topical Acetylcholine (Ach) application, and maximum amplitudes (MA) of the evoked contraction were compared. Clear tonic patterns were observed in the ileal motility after Ach application. After short-term stress, there were no significant differences in MA between control and Sansho-intake groups in both sexes. However, after long-term stress-loading, significant enhancement of MA was observed in Sansho-intake group in males, but not in females. The present study showed that SAN affected Ach-induced ileal motility in the male, but not in the female after long-term stress loading, indicating sex differences in effects of Sansho intake. It is suggested that Sansho is more effective in males than in females to decrease negative stress response.
    VL  - 3
    IS  - 3-1
    ER  - 

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Author Information
  • Physiological Laboratories, Japan Women's University, Tokyo, Japan

  • Graduate Program in Health Science and Technology, University of Brasilia, Brasilia, Brazil

  • Laboratory of Biochemistry and Food Biology, Japan Women's University, Tokyo, Japan

  • Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

  • Physiological Laboratories, Japan Women's University, Tokyo, Japan

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